Christina Chan
Chairperson – Chemical Engineering and Materials Science (ChEMS)
Chemical Engineering and Materials Science (ChEMS), College of Engineering
University Distinguished Professor - Chemical Engineering and Materials Science (ChEMS) in the College of Engineering
Institute for Quantitative Health Science & Engineering
Engineering Bldg, 428 S Shaw Ln Room 1243
Biography
Our laboratory applies cellular, molecular engineering and systems biology approaches to investigate disease mechanisms. We are studying endoplasmic reticulum (ER) stress related diseases, in particular, we are interested in how fatty acids interact with ER transmembrane sensor proteins to drive the development of cancer metastasis and neurological diseases. Our laboratory also is developing therapeutics ... using engineering approaches (e.g. drug delivery systems and stem cell engineering techniques) to modulate the pathways altered in these diseases.
Read MoreEducation
Ph.D, Chemical and Biochemical Engineering, University of Pennsylvania 1990
M.S., Chemical and Biochemical Engineering, University of Pennsylvania 1986
B.S., Chemical Engineering, Columbia University 1984
Awards
Recipient of the AIChE Area Forum 15D/E Engineering Fundamentals in Life Science Plenary Lecture Award, 2015
Beal Outstanding Faculty Award (formerly University Distinguished Faculty Award), 2014
Engineering's College of Fellows, 2012
Elected to the American Institute for Medical and Biological, 2011
... Read MorePublications
Splichal, R. C., Chen, K., Walton, S. P., Chan, C., "The Role of Endoplasmic Reticulum Stress on Reducing Recombinant Protein Production in Mammalian Cells", (2024) Biochemical Engineering Journal, https://doi.org/10.1016/j.bej.2024.109434
Aleksandra Kostina; Yonatan R. Lewis-Israeli; Mishref Abdelhamid; Mitchell A. Gabalski; Artem Kiselev, Brett D. Volmert; Haley Lankerd; Amanda R. Huang; Aaron H. Wasserman; Todd Lydic; Christina Chan; Isoken Olomu; Aitor Aguirre, “ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes”, (2023) Cell Stem Cell, 19: 317-330.
Thompson, R., Mazur, N., Yang, J., and Chan, C., "Soft Substrates Induce Neural Differentiation via the Neuron Restrictive Silencer Factor", (2022) Biochemical Engineering Journal, 189: 108724.
Lawson, H. D., Walton, S. P., and Chan, C., “Metal−Organic Frameworks for Drug Delivery: A Design Perspective”, (2021) ACS Applied Materials & Interfaces, 13(6): 7004–7020.